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Index > Protein center > Duox2(Gene name) > Rat
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  • Duox2 (Gene name),
  • Dual oxidase 2 (Protein name ),  DUOX2_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Duox2(Lnox2;Thox2);
    Protein name:
    Dual oxidase 2;
    Alternative:
    Long NOX 2;Large NOX 2;Thyroid oxidase 2;NADH/NADPH thyroid oxidase THOX2;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with TXNDC11, TPO and CYBA.
    Function:
    Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
    Subcellular Location:
    Apical cell membrane Multi-pass membrane protein Localizes to the apical membrane of epithelial cells.
    Protein Attributes:
    Sequence length:
    1517
    Sequence:
    50:
    MLPTSLKTLV | LLGALLTGPL | GPAGGQDAPS | LPREVQRYDG | WFNNLKYHQR | 
    100:
    GAAGSQLRRL | VPANYADGVY | QALQEPLLPN | ARLLSDAVSK | GKAGLPSAHN | 
    150:
    RTVLGLFFGY | HVLSDLVSVE | TPGCPAEFLN | IYIPRGDPVF | DPDKRGNVVL | 
    200:
    PFQRSRWDRS | TGQSPSNPRD | LTNQVTGWLD | GSAIYGSSHS | WSDTLRSFSG | 
    250:
    GQLASGPDPA | FPRNSQNSLL | MWMAPDPATG | QGGPQGLYAF | GAQRGNREPF | 
    300:
    LQALGLLWFR | YHNLCAKRLA | QEHPHWGDEE | LFQHARKRVI | ATYQNIALYQ | 
    350:
    WLPSFLQKTP | PEYSGYRPFM | DPSISPEFVA | ASEQFLSTMV | PPGVYMRNSS | 
    400:
    CHFREFPKEG | SSSSPALRVC | NNYWIRENPS | LKTAQDVDQL | LLGMASQISE | 
    450:
    LEDRIVIEDL | RDYWPGPDRY | SRTDYVASSI | QSGRDMGLPS | YSQALQALGL | 
    500:
    EPPKNWSALN | PKVDPQVLEA | TAALYNQDLS | RLELFLGGLL | ESHGDPGPLF | 
    550:
    SNIILDQFVR | LRDGDRYWFE | NTRNGLFSKE | EIAEIRNTTL | RDVLVAVSNV | 
    600:
    DPSALQPNVF | FWQEGAPCPQ | PQQLTTEGLP | QCVPVTVIDY | FEGSGAGYGV | 
    650:
    TLLAVCCFPV | VSLIIAWVVA | RFRNRERKML | LKKGKESLKK | QTASDGVPAM | 
    700:
    EWPGPKESSY | PVTVQLLPDR | SLKVLDKRLT | VLRTIQLQPT | QQVNLILSSS | 
    750:
    HGRRTLLLKI | PKEYDLVLMF | NSEEDRDAFV | QLLQDLCVCS | TPGLRIAEMD | 
    800:
    EKELLRKAVT | KQQRAGILEI | FFRQLFAQVL | DINQADAGTL | PLDSSQQVRE | 
    850:
    ALTCELSRAE | FADSLGLKPQ | DMFVESMFSL | ADKDGNGYIS | FREFLDILVV | 
    900:
    FMKGSPQDKS | RLMFTMYDLD | GNGFLSKEEF | FTMMRSFIEI | SNNCLSKDQL | 
    950:
    AEVVESMFRE | SGFQDKEELT | WEDFHFMLRD | HDSDLRFTQL | CVKGGAGGTG | 
    1000:
    DIFKQSNACR | VSFLTRTPGN | RVMAPSPRLY | TEALQEKMQR | GFLAQKLKQF | 
    1050:
    KRFVENYRRH | IVCVTIFSAI | CAGLFADRAY | YYGFASPPTD | IEETTYVGII | 
    1100:
    LSRGTAASIS | FMFSYILLTM | CRNLITFLRE | TFLNRYIPFD | AAVDFHRWIA | 
    1150:
    MAAVVLAVVH | SLGHAVNVYI | FSVSPLSLMT | CVFPSVFVND | GSKLPPKYYW | 
    1200:
    WFFETVPGMT | GVLLLLVLAI | MYVFASHHFR | RHSFRGFWLT | HHLYVVLYAL | 
    1250:
    IIIHGSYALI | QLPSFHIYFL | VPAIIYVGDK | LVSLSRKKVE | ISVVKVELLP | 
    1300:
    SGVTYLQFQR | PKTFEYKSGQ | WVRIACLSLG | TNEYHPFTLT | SAPHEDTLSL | 
    1350:
    HIRAVGPWTT | RLREIYSPPV | GGTSARYPKL | YLDGPFGEGH | QEWHKFEVSV | 
    1400:
    LVGGGIGVTP | FASILKDLVF | KSSMGTQMLC | KKIYFIWVTR | TQRQFEWLAD | 
    1450:
    IIREVEENGS | RDLVSVHIYI | TQLAEKFDLR | TTMLYICERH | FQKVLNRSLF | 
    1500:
    TGLRSVTHFG | RPPFELFLDS | LQEVHPQVHK | IGVFSCGPPG | MTKNVEKACQ | 
    1517:
    LINRQDRAHF | VHHYENF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Dual oxidase 2
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    E9487h
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    Packing:
    96T
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    ELISA Kit for Rat Dual oxidase 2
    Cat.:
    E9487r
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    Packing:
    96T
    ELISA Kit for Rat Dual oxidase 2
    Cat.:
    E9487p
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    Packing:
    96T
    CLIA Kit for Rat Dual oxidase 2
    Cat.:
    U9487r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Dual oxidase 2
    Cat.:
    U9487h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Dual oxidase 2
    Cat.:
    U9487p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Dual oxidase 2
    Cat.:
    P9487Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Dual oxidase 2
    Polyclonal Antibody for Rat Dual oxidase 2
    Monoclonal Antibody for Rat Dual oxidase 2
    Monoclonal Antibody for Rat Dual oxidase 2
    Monoclonal Antibody for Rat Dual oxidase 2
    Protein for Rat Dual oxidase 2
    Protein for Rat Dual oxidase 2
    Protein for Rat Dual oxidase 2

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    Precision
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    Linearity
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    References
    1. 1.
      "Thyroid oxidase (THOX2) gene expression in the rat thyroid cell line FRTL-5."
      Dupuy C. , Pomerance M. , Ohayon R. , Noel-Hudson M.-S. , Deme D. , Chaaraoui M. , Francon J. , Virion A.
      Biochem. Biophys. Res. Commun.277:287-292(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;INDUCTION
      tissue: Thyroid.
    2. 2.
      "Identification of a truncated dual oxidase 2 (DUOX2) messenger ribonucleic acid (mRNA) in two rat thyroid cell lines. Insulin and forskolin regulation of DUOX2 mRNA levels in FRTL-5 cells and porcine thyrocytes."
      Morand S. , Dos Santos O.F. , Ohayon R. , Kaniewski J. , Noel-Hudson M.-S. , Virion A. , Dupuy C.
      Endocrinology144:567-574(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INDUCTION
      strain: Fischer.
    3. 3.
      "Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense."
      Geiszt M. , Witta J. , Baffi J. , Lekstrom K. , Leto T.L.
      FASEB J.17:1502-1504(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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