Gene name:
Duox2 (Lnox2;Thox2) ;
Protein name:
Dual oxidase 2 ;
Alternative:
Long NOX 2 ;Large NOX 2 ;Thyroid oxidase 2 ;NADH/NADPH thyroid oxidase THOX2 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with TXNDC11, TPO and CYBA.
Function:
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Subcellular Location:
Apical cell membrane
Multi-pass membrane protein
Localizes to the apical membrane of epithelial cells.
Protein Attributes:
50:
MLPTSLKTLV | LLGALLTGPL | GPAGGQDAPS | LPREVQRYDG | WFNNLKYHQR |
100:
GAAGSQLRRL | VPANYADGVY | QALQEPLLPN | ARLLSDAVSK | GKAGLPSAHN |
150:
RTVLGLFFGY | HVLSDLVSVE | TPGCPAEFLN | IYIPRGDPVF | DPDKRGNVVL |
200:
PFQRSRWDRS | TGQSPSNPRD | LTNQVTGWLD | GSAIYGSSHS | WSDTLRSFSG |
250:
GQLASGPDPA | FPRNSQNSLL | MWMAPDPATG | QGGPQGLYAF | GAQRGNREPF |
300:
LQALGLLWFR | YHNLCAKRLA | QEHPHWGDEE | LFQHARKRVI | ATYQNIALYQ |
350:
WLPSFLQKTP | PEYSGYRPFM | DPSISPEFVA | ASEQFLSTMV | PPGVYMRNSS |
400:
CHFREFPKEG | SSSSPALRVC | NNYWIRENPS | LKTAQDVDQL | LLGMASQISE |
450:
LEDRIVIEDL | RDYWPGPDRY | SRTDYVASSI | QSGRDMGLPS | YSQALQALGL |
500:
EPPKNWSALN | PKVDPQVLEA | TAALYNQDLS | RLELFLGGLL | ESHGDPGPLF |
550:
SNIILDQFVR | LRDGDRYWFE | NTRNGLFSKE | EIAEIRNTTL | RDVLVAVSNV |
600:
DPSALQPNVF | FWQEGAPCPQ | PQQLTTEGLP | QCVPVTVIDY | FEGSGAGYGV |
650:
TLLAVCCFPV | VSLIIAWVVA | RFRNRERKML | LKKGKESLKK | QTASDGVPAM |
700:
EWPGPKESSY | PVTVQLLPDR | SLKVLDKRLT | VLRTIQLQPT | QQVNLILSSS |
750:
HGRRTLLLKI | PKEYDLVLMF | NSEEDRDAFV | QLLQDLCVCS | TPGLRIAEMD |
800:
EKELLRKAVT | KQQRAGILEI | FFRQLFAQVL | DINQADAGTL | PLDSSQQVRE |
850:
ALTCELSRAE | FADSLGLKPQ | DMFVESMFSL | ADKDGNGYIS | FREFLDILVV |
900:
FMKGSPQDKS | RLMFTMYDLD | GNGFLSKEEF | FTMMRSFIEI | SNNCLSKDQL |
950:
AEVVESMFRE | SGFQDKEELT | WEDFHFMLRD | HDSDLRFTQL | CVKGGAGGTG |
1000:
DIFKQSNACR | VSFLTRTPGN | RVMAPSPRLY | TEALQEKMQR | GFLAQKLKQF |
1050:
KRFVENYRRH | IVCVTIFSAI | CAGLFADRAY | YYGFASPPTD | IEETTYVGII |
1100:
LSRGTAASIS | FMFSYILLTM | CRNLITFLRE | TFLNRYIPFD | AAVDFHRWIA |
1150:
MAAVVLAVVH | SLGHAVNVYI | FSVSPLSLMT | CVFPSVFVND | GSKLPPKYYW |
1200:
WFFETVPGMT | GVLLLLVLAI | MYVFASHHFR | RHSFRGFWLT | HHLYVVLYAL |
1250:
IIIHGSYALI | QLPSFHIYFL | VPAIIYVGDK | LVSLSRKKVE | ISVVKVELLP |
1300:
SGVTYLQFQR | PKTFEYKSGQ | WVRIACLSLG | TNEYHPFTLT | SAPHEDTLSL |
1350:
HIRAVGPWTT | RLREIYSPPV | GGTSARYPKL | YLDGPFGEGH | QEWHKFEVSV |
1400:
LVGGGIGVTP | FASILKDLVF | KSSMGTQMLC | KKIYFIWVTR | TQRQFEWLAD |
1450:
IIREVEENGS | RDLVSVHIYI | TQLAEKFDLR | TTMLYICERH | FQKVLNRSLF |
1500:
TGLRSVTHFG | RPPFELFLDS | LQEVHPQVHK | IGVFSCGPPG | MTKNVEKACQ |
1517:
LINRQDRAHF | VHHYENF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Pig
ELISA Kit for Rat Dual oxidase 2
ELISA Kit for Rat Dual oxidase 2
ELISA Kit for Rat Dual oxidase 2
CLIA Kit for Rat Dual oxidase 2
CLIA Kit for Rat Dual oxidase 2
CLIA Kit for Rat Dual oxidase 2
Polyclonal Antibody for Rat Dual oxidase 2
Polyclonal Antibody for Rat Dual oxidase 2
Polyclonal Antibody for Rat Dual oxidase 2
Monoclonal Antibody for Rat Dual oxidase 2
Monoclonal Antibody for Rat Dual oxidase 2
Monoclonal Antibody for Rat Dual oxidase 2
Protein for Rat Dual oxidase 2
Protein for Rat Dual oxidase 2
Protein for Rat Dual oxidase 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;INDUCTION
tissue :
Thyroid .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INDUCTION
strain :
Fischer .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY